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SCHOOL OF BIOLOGICAL SCIENCES

Intan Haslina Ishak, Dr

Phone (ext): 5137
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USM Expert

 Research background

Mosquito-borne diseases continue to pose major public health challenges in tropical regions. Chemical insecticides remain a key component of vector control programmes. However, the rapid emergence of insecticide resistance in mosquito populations threatens their effectiveness. My research focuses on understanding the biological, physiological, and molecular mechanisms underlying insecticide resistance in mosquito vectors, particularly Aedes aegypti, Aedes albopictus and Culex spp, by investigating the biological, physiological, and molecular mechanisms underlying resistance. Current work also investigates the impact of climate-related abiotic stressors on the development and expression of resistance in Aedes. In addition, I conduct efficacy evaluations of insecticides against medically and economically important pests, including stored product pests, darkling beetles, and cockroaches.

Research focus

Molecular Entomology, Public Health Entomology, Integrated Pest Management

Selected publications

  1. Shettima A, Ishak, I. H., Lau B, Abu Hasan H, Miswan N. & Nurulhasanah Othman (2023). Quantitative proteomics analysis of permethrin and temephos-resistant Ae. aegypti revealed diverse differentially expressed proteins associated with insecticide resistance from Penang Island, Malaysia. PLOS Neglected Tropical Diseases - https://doi.org/10.1371/journal.pntd.0011604
  2. Rajiv Ravi, Dinesh Rajendran, Wen-Da Oh, Mohd Sukhairi Mat Rasat, Zulhazman Hamzah, Intan H. Ishak & Mohamad Faiz Mohd Amin. (2020). The potential use of Azolla pinnata as an alternative bio-insecticide. Scientific Reports - https://www.nature.com/articles/s41598-020-75054-0
  3. Akhir, M., Wajidi, M., Lavoué, S., Azzam, G., Jaafar, I. S., Awang Besar, N., Intan H. Ishak. (2022). Knockdown resistance (kdr) gene of Aedes aegypti in Malaysia with the discovery of a novel regional specific point mutation A1007G. Parasites & vectors, 15(1), 122. https://doi.org/10.1186/s13071-022-05192-z
  4. Intan H. Ishak, Zairi Jaal, Hilary Ranson and Charles S. Wondji. (2015). Contrasting Patterns of Insecticide Resistance and Knockdown Resistance (kdr) in the Dengue Vectors Aedes aegypti and Aedes albopictus from Malaysia. Parasites and Vectors - https://link.springer.com/article/10.1186/s13071-015-0797-2