yahya

 

Associate Professor
B.Sc., University of Missouri, USA
Ph.D., Purdue University, USA
Ext. 4013; ymarip@usm.my
Molecular Virology and Biotechnology

 

Research Profile

Research focuses on the assembly process of dengue virus. The interest is in the macromolecular interactions involve in virus assembly process, such as, protein/protein, protein/nucleic acid and nucleic acid/nucleic acid interactions.

Another interest is genetic engineering-manipulation of DNA and production of recombinant protein. This also includes genetic modifications of microorganism, such as recombinant virus.

Current Research

 

  • Construction of dengue virus cDNA clone
  • Molecular interaction involves in nucleocapsid formation of dengue virus
  • Dengue virus replication process with focus on RNA-dependent RNA polymerase (RdRp) and RNA helicase
  • Production of recombinant biopharmaceutical – human growth hormone

Collaborators

  • Universiti Malaya

Selected Publications

  • Mat-Arip, Y., K. Garver, C. Chen, S. Sheng, Z. Shao and P. Guo. 2001. Threedimensional interaction of phi29 pRNA dimmer probed by chemical modifi cation interference, cryo-AFM, and cross-linking. J. Biol. Chem. 276: 32575-32584.
  • Trottier, M., Y. Mat-Arip, C. Zhang, C. Chen, S. Sheng, Z. Shao and P. Guo. 2000. Probing the structure of monomers and dimers of the bacterial virus phi29 hexamer RNA complex by chemical modifi cation. RNA 6: 1257-1266.
  • Huang, Q., Y. Mat-Arip and P. Guo. 1997. Sequencing of a 5.5-kb DNA fragment and identification of a gene coding for a subunit of the helicase/primase complex of avian laryngotracheitis virus (ILTV). Virus Genes 15:119-121

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