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     Siti Nasuha                         

B. App Sc. (Hons) (Biology and Management of Vectors and Parasites), Universiti Sains Malaysia.
M.Sc. (Medical Entomology), Universiti Sains Malaysia.
Ph.D. (Proteomics, Biochemistry) University of Malaya.
Ext. 4061
sitinasuha@usm.my 

Research Profile

Management of insecticide resistance is a big challenge especially in an agricultural and household important pest and also in human disease vectors. Different resistance mechanisms include altered target site insensitivity, decreased penetration, and metabolic resistance mediated by detoxifying enzymes. Its offers the insects to escape from its toxicants, however insecticide resistance management will be possible, if the underlying mechanisms known in a particular pest. Biochemical characteristics and gene expression profiles of the metabolic detoxification enzymes is of significant importance in understanding the phenomenon of resistance development.
My main research interests focus on;
• occurrence of detoxification enzymes in human disease vectors and in agricultural & household important pests,
• understanding of role of detoxification enzymes in insecticide resistance,
• cellular functions of proteome of detoxification enzymes,
• stress-response proteins as markers of toxicity in laboratory and environmental toxicology;
• integrated control approaches for vector and pest management,
• surveillance, management and mechanisms of insecticide resistance,
• development of common household insecticide products and its effect to the detoxification system of vector mosquitoes.
Approaches of the study involve the techniques of biochemistry, proteomics, molecular biology, biophysical analysis, bioassays, lab and field surveillance, classification system and chemical testing and analysis.

Current Research

 

• To elucidate the role of resistance mechanism and involvement of glutathione S-transferases in development of insecticide resistance.
• Investigating the effect of xenobiotic challenges on the detoxification enzyme of the vectors.
• Repellent and toxic effects of selected plant extraction on the dengue vector.

Collaborators

• Proteomic Laboratory, Biochemistry Department, ISB, University of Malaya.
• Entomology Unit, Institute of Medical Research (IMR).
• Vector Control Unit, Department of Health and Environment, Kuala Lumpur City Hall (DBKL).
• Pest Control Unit, Department of Health and Environment, Kuala Lumpur City Hall (DBKL).
• Department of Frontier Fiber Technology and Science, University Fukui, Japan.

Memberships:

Malaysian Society of Parasitology and Tropical (Member)

Selected Publications

Published papers

Hamzah, S.N. & Alias, Z. (2016). Developmental expression and oxidative stress induction of proteome of Glutathione Transferases in Aedes albopictus (Diptera: Culicidae). Journal of Asian Pasific Entomology 19: 869-875 (ISI-Indexed) DOI: 10.5772/61972
Hamzah, S.N. & Alias, Z. (2016). Purification, expression and partial characterization of glutathione s-transferases (GSTs) from three different strains of Aedes albopictus (Diptera: Culicidae). Tropical Biomedicine 33(2): 35-347 (ISI-Indexed).

Proceedings, Posters, Presentations.

Hamzah, S.N. & Alias, Z. (2015). Expression of Aedes albopictus Glutathione S-tranferases (GSTs) in response to chemical challenges. The Seoul International Conference on Life Sciences and Biological Engineering. Time Square, Seoul Korea 8-10 January 2015.
Hamzah, S.N. & Alias, Z. (2014). Differences in Aedes albopictus Glutathione S-transferases (GSTs) expression in response to oxidative stress. 6th ASEAN Congress of Tropical Medicine and Parasitology. InterContinental, Kuala Lumpur 5-7 March 2014.
Hamzah, S.N. & Alias, Z. (2013). Expression of Glutathione transferases (GSTs) isoforms in Aedes albopictus in response to oxidative stress and insecticide challenge. Workshop for International Student Exchange Program between Diverse Research Fields. University of Fukui, Fukui Japan 26 August 2013. Pp 14.
Hamzah, S.N. & Alias, Z. (2012). The proteome of Aedes albopictus Glutathione S-transferases. Seminar Calon Ph.D & Sarjana. University of Malaya, Kuala Lumpur 21 December 2012.
Hamzah, S.N. & Alias, Z. (2012). Multiple isoforms of glutathione transferases in different developmental stages of Aedes albopictus. The 17th Biological Sciences Graduate Congress 2012. Chulalongkorn University, Bangkok Thailand 8- 10 December 2012.
Hamzah, S.N. & Jaal, Z. (2010). Effect to biology of Culex quinquefasciatus (Say) mosquitoes after blood feeding through membrane feeding method and its blood preference. 46th Annual Scientific Seminar, Malaysia Society of Parasitology and Tropical Medicine. Grand Season, Kuala Lumpur 24-25 March 2010. Pp 67.
Hamzah, S.N. & Jaal, Z. (2009). Biological study of adult, larvae and pupae Culex quinquefasciatus (Say) mosquitoes in Pulau Pinang. Symposium of USM Fellowhip Holders 2009. Universiti Sains Malaysia, Pulau Pinang 14- 15 November 2009.
Hamzah, S.N. & Jaal, Z. (2009). Bionomic Studies of Culex quinquefasciatus mosquito on Penang Island. PPSKH/IPS Colloqium 2009. Universiti Sains Malaysia, Pulau Pinang 14th May 2009.
Hamzah, S.N. & Jaal, Z. (2009). Adult seasonal abundance of Culex quinquefasciatus (Say) mosquitoes in Pulau Pinang. UNAIR – USM Second Collaboration Conference. Airlangga University, Surabaya, Indonesia 10-11 February 2009. Pp 200.
Hamzah, S.N. & Jaal, Z. (2008). Biting Cycle of Culex quinquefasciatus (Say) mosquitoes in Pulau Pinang. 10th Symposium, Malaysia Society of Applied Biology. Merdeka Palace, Kuching, Sarawak 6-8 November 2008. Pp 44.
Jaal, Z., & Hamzah, S.N. (2008). “Global Warming and Its Impact on Pest Management”. Pest Summit, Bangkok, Thailand 13-15 August 2008.
Hamzah, S.N., Sulaiman, I. & Jaal, Z. (2008). Biological study of Culex brevipalpis (Giles) (Diptera: Culicidae) mosquitoes in the laboratory. 44th Annual Scientific Seminar, Malaysia Society of Parasitology and Tropical Medicine. Grand Season, Kuala Lumpur 4-5 March 2008.

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